Three people have passed on after a 6.4-magnitude struck southern Turkey on Monday, weeks after a deadly earthquake devastated the region.
In excess of 680 people have been injured in Turkey and Syria.
Turkey's disaster and emergency agent Afad said the quake happened at 20:04 local time (17:04 GMT), trailed by many dozens of aftershocks.
A 7.8-magnitude quake struck similar region on 6 February, killing more than 44,000 people in Turkey and Syria.
Those killed by Monday's quake were tracked down in Antakya, Defne, and Samandagi, Interior Minister Süleyman Soylu said, asking people not to enter possibly hazardous buildings.
Mr Soylu said 213 people had been injured in Turkey.
Witnesses told the Reuters news agency there had been further harm to building in Antakya, while the city mayor of Hatay, in southern Turkey, said people were trapped under rubble.
"I thought the earth was going to divide open under my feet," Muna al-Omar, a local resident, told Reuters, crying as she held her seven-year-old child. She was in a tent in a park in central Antakya when the most recent tremor hit, she said.
Turkish authorities have recorded more than 6,000 aftershocks since the 6 February earthquake, yet the BBC's team in the region said the most recent earthquake felt a lot more stronger than past ones.
The Syrian Observatory for Human Rights said 470 injured people had visited hospitals after the quake, which was additionally allegedly felt in Egypt and Lebanon.
Afad said there were 32 aftershocks following Monday's quake, the biggest of which had an magnitude of 5.8.
There is fear and panic in the streets-lines of ambulances and rescue crews are attempting to get to a some of the most terrible affected area where the walls of gravely damage building have collapse.
Various structures that were left remaining after the quake on 6 February have now disintegrated, including a bridge. Many cracks in roads have become profound scars making it more hard for the emergency service to get where they might be needed.
An AFP journalist wrote about scenes of panic in Antakya, the capital of Hatay Territory which was at already devastated by the previous earthquake - with the most recent quakes bringing dust storms up in the city.
The walls of building also disintegrated, AFP reports, with several apparently injured people calling for help.
Ali Mazlum said he was searching for the bodies of relatives from the past tremor when the most recent one hit.
"You don't have the foggiest idea what to do… we grabbed one another and directly before us, the walls began to fall. It seemed like the earth was opening up to swallow us up," he said.
In a tweet, Afad at first encouraged people to avoid shores as a safety measure against the risk of rising ocean levels, albeit the warning was later removed.