Manchester United produced a memorable second half rebound to reach at the Europa League last 16 and take out Barcelona simultaneously.
Brazilian pair Fred and Antony, who came on as a half-time substitute, both bored home low first-time shots before a happy Stretford End.
It was a triumph that looked so far-fetched at half-time as Barcelona drove thanks to Robert Lewandowski's eighteenth moment punishment after Bruno Fernandes' unnecessary foul on Alejandro Balde.
However, Antony's appearance for battling forward Wout Weghost steered the tie as it infused more speed into Joined's assaults, which the La Liga leader failed to manage.
Erik ten Hag side currently continue on toward Wembley, where they will hope to gather their most memorable flatware starting around 2017 when they face Newcastle in the EFL Cup last.
For Barcelona, it was whenever they first have been killed from European rivalry without arriving at the last 16 beginning around 1998-1999, which isn't exactly what president Joan Laporta had as a primary concern when he pulled that multitude of financial switches a year ago.
It was additionally Barcelona's most memorable loss since October and finished a 18-match unbeaten run.
After the match, Ten Witch said: "It was a great evening. I think this is another step since when you can beat Barcelona - quite possibly of the best group at this time in Europe - your conviction can be major areas of strength for truly then I think you can beat anybody.
"I think we have extraordinary characters… winning sorts.
"Everybody has a such a sincere faith in this group and battle in this group and you can see it with the subs, they are bringing energy and quality and an alternate unique in games. Every one of the subs, not just in this game, did splendid."