Chelsea will face holders Real Madrid in the Champions League quarter-finals.
Pep Guardiola faces his former club as Manchester City play six-time winners Bayern Munich.
Inter Milan face Benfica and Serie A champions AC Milan take on current leaders Napoli.
Assuming Chelsea and Manchester City get past, they will meet in an all-Premier League semi-final while AC Milan or Napoli will face Inter Milan or Benfica in the other semi-final.
The first legs of the quarter-finals happen on 11-12 April, with the return games on 18-19 April.
The first legs of the semi-finals will be on 9-10 May, and the second legs on 16-17 May.
The Ataturk Olympic Stadium in Istanbul, Turkey, will host the final on 10 June.
Champions League quarter-final draw
Real Madrid v Chelsea
Inter Milan v Benfica
Manchester City v Bayern Munich
AC Milan v Napoli
Champions League semi-final draw
AC Milan or Napoli v Benfica or Inter Milan
Real Madrid or Chelsea v Manchester City or Bayern Munich
'Furiously intense courses' - analysis
Phil McNulty, BBC Sports chief football writer
Chelsea and Manchester City have been given furiously extreme courses towards the Champions League final in Istanbul.
Graham Potter's Chelsea have improved as of late however they will be firm longshots against holders Real Madrid, who discarded Liverpool effortlessly in the last 16. Real are driven by former Chelsea boss Carlo Ancelotti, the only manager to win the tournament multiple times.
Manchester City, looking for their first Champions League crown, will be favourites against Bayern Munich however the Bundesliga champions have such a rich history in the competition and demonstrated their pedigree by knocking out Paris St-Germain. They can never be underestimated.
Bayern likewise have fit-again former Liverpool striker Sadio Mane, who was a consistent thistle in the side of City and manager Pep Guardiola during a heavenly career at Anfield, which incorporated a Champions League win and two losses in the final.
With the last-four draw likewise made, there is presently the chance of an all-English semi-last should Chelsea and City progress.
However, until further notice both Potter and Guardiola realize they should explore a far beyond two goliaths of the Champions League who will be loaded up with conviction that they can defeat the Premier League clubs.